TOK-001 (Galeterone)

Catalog No. A11138

TOK-001 (Galeterone)既是雄激素受体拮抗剂又是CYP17A1抑制剂。

Technical details

Catalog Num	A11138
M. Wt	388.3
Formula	C26H32N2O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	851983-85-2
Synonyms	VN/124-1
SMILES	C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4N5C=NC6=CC=CC=C65)C)O

Biological Activity

TOK-001 (Galeterone)既是雄激素受体拮抗剂又是CYP17A1抑制剂。

Targets

CYP17	Androgen Receptor
300 nM	384 nM

Solubility *

In vitro (25°C)	DMSO	21 mg/mL (54.04 mM)
	Water	Insoluble
	Ethanol	Warmed: 36 mg/mL (92.65 mM)
In vivo	0.5% hydroxyethyl cellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.75 mL	128.77 mL	257.53 mL
0.5 mM	5.15 mL	25.75 mL	51.51 mL
1 mM	2.58 mL	12.88 mL	25.75 mL
5 mM	0.52 mL	2.58 mL	5.15 mL

*The above data is based on the productmolecular weight 388.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.