PF 431396

Catalog No. A11142

PF 431396是一种双粘着斑激酶（FAK）和富含脯氨酸的酪氨酸激酶2（PYK2）抑制剂（IC50值分别为2和11 nM）。

Technical details

Catalog Num	A11142
M. Wt	506.5
Formula	C22H21F3N6O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	717906-29-1
Synonyms	PF-431396
SMILES	CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C

Biological Activity

PF 431396是一种双粘着斑激酶（FAK）和富含脯氨酸的酪氨酸激酶2（PYK2）抑制剂（IC50值分别为2和11 nM）。

Targets

FAK	PYK2
2 nM	11 nM

Solubility *

In vitro	DMSO	94 mg/mL (185.58 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.74 mL	98.72 mL	197.43 mL
0.5 mM	3.95 mL	19.74 mL	39.49 mL
1 mM	1.97 mL	9.87 mL	19.74 mL
5 mM	0.39 mL	1.97 mL	3.95 mL

*The above data is based on the productmolecular weight 506.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.