TH-302 (Evofosfamide)

Catalog No. A11144

TH-302 (Evofosfamide)是选择性靶向实体瘤缺氧激活的前体药物，靶向作用于实体瘤的hypoxic区域，IC50为19 nM，在缺氧条件下比在有氧条件下细胞毒性增强270倍，细胞色素P450代谢稳定。

Product Citations

Anirudh Sattiraju, .et al. Spatial patterning and immunosuppression of glioblastoma immune contexture in hypoxic niches, bioRxiv, 2022, March 04

Technical details

Catalog Num	A11144
M. Wt	449.0
Formula	C9H16Br2N5O4P
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	918633-87-1
Synonyms	TH302
SMILES	CN1C(=CN=C1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr

Biological Activity

Targets

Solubility *

In vitro (25°C)	DMSO	80 mg/mL (178.15 mM)
	Water	Warmed: 9 mg/mL (20.03 mM)
	Ethanol	80 mg/mL (178.15 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.27 mL	111.36 mL	222.72 mL
0.5 mM	4.45 mL	22.27 mL	44.54 mL
1 mM	2.23 mL	11.14 mL	22.27 mL
5 mM	0.45 mL	2.23 mL	4.45 mL

*The above data is based on the productmolecular weight 449.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.