BX-795

Catalog No. A11148

BX-795是有效的PDK1抑制剂，可阻断肿瘤细胞中的PDK1/Akt信号传导并抑制培养物中多种肿瘤细胞系的锚定依赖性生长或诱导凋亡。

Product Citations

Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Technical details

Catalog Num	A11148
M. Wt	591.5
Formula	C23H26IN7O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	702675-74-9
Synonyms	BX795
SMILES	C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I

Biological Activity

BX-795是有效的PDK1抑制剂，可阻断肿瘤细胞中的PDK1/Akt信号传导并抑制培养物中多种肿瘤细胞系的锚定依赖性生长或诱导凋亡。

Targets

Target	Value
TBK1/IKK?
PDK-1	IC50: 6nM
c-Kit	IC50: 320nM
CDK2/CyclinE	IC50: 430nM
Chk1	IC50: 510nM
GSK-3β	IC50: 620nM
PKA	IC50: 840nM
KDR	IC50: 1.1μM
T-Fyn	IC50: 6.4μM
PKC	IC50: 9.3μM
EGFR	IC50: >10μM
Insulin Receptor	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	88 mg/mL (148.78 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG +2% Tween 80+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.91 mL	84.53 mL	169.06 mL
0.5 mM	3.38 mL	16.91 mL	33.81 mL
1 mM	1.69 mL	8.45 mL	16.91 mL
5 mM	0.34 mL	1.69 mL	3.38 mL

*The above data is based on the productmolecular weight 591.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.