BMS-265246

Catalog No. A11154

BMS-265246是cdk2/cyclin E和cdk1/cyclin B以及cdk4/cyclin D的强新吡唑并吡啶抑制剂。

Technical details

Catalog Num	A11154
M. Wt	345.3
Formula	C18H17F2N3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	582315-72-8
Synonyms	BMS265246
SMILES	CCCCOC1=C2C=NNC2=NC=C1C(=O)C3=C(C=C(C=C3F)C)F

Biological Activity

BMS-265246是cdk2/cyclin E和cdk1/cyclin B以及cdk4/cyclin D的强新吡唑并吡啶抑制剂。

Targets

CDK1/CyclinB (Cell-free assay)	CDK2/CyclinE (Cell-free assay)	CDK4/CyclinD (Cell-free assay)
6 nM	9 nM	230 nM

Solubility *

In vitro (25°C)	DMSO	18 mg/mL (52.12 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.96 mL	144.8 mL	289.6 mL
0.5 mM	5.79 mL	28.96 mL	57.92 mL
1 mM	2.9 mL	14.48 mL	28.96 mL
5 mM	0.58 mL	2.9 mL	5.79 mL

*The above data is based on the productmolecular weight 345.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.