BGJ398 (NVP-BGJ398)

Catalog No. A11159

BGJ398 (NVP-BGJ398)是一种有效的选择性抑制剂，具有成纤维细胞生长因子受体（FGFR）酪氨酸激酶1、2、3和4的潜在抗血管生成和抗肿瘤活性（对于FGFR1，FGFR2，FGFR3，IC50值为0.9、1.4、1.0和60 nM，和FGFR4）。

Product Citations

Takehito Yamamoto, .et al. Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor Therapy, Cancers (Basel), 2020, Jul 22;12(8):E2010 PMID: 32708005
Daniel Limonta, .et al. Fibroblast growth factor 2 enhances Zika virus infection in human fetal brain, J Infect Dis, 2019, 2019 PMID: 30799482
Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
Anil Kumar, .et al. Human Sertoli cells support high levels of Zika virus replication and persistence, Sci Rep, 2018, 8: 5477 PMID: 29615760

Technical details

Catalog Num	A11159
M. Wt	560.48
Formula	C26H31Cl2N7O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	872511-34-7
Synonyms	BGJ-398
SMILES	CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl

Biological Activity

Targets

Target	Value
FGFR1	IC50: 0.9nM
FGFR3	IC50: 1.0nM
FGFR2	IC50: 1.4nM
FGFR3(K650E)	IC50: 4.9nM
FGFR4	IC50: 60nM
VEGFR2	IC50: 0.18μM
Lyn	IC50: 0.30μM
Kit	IC50: 0.75μM
YES	IC50: 1.1μM
Fyn	IC50: 1.9μM
Abl	IC50: 2.3μM
LCK	IC50: 2.5μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 1 mg/mL (1.78 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1%CMC-Na	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.84 mL	89.21 mL	178.42 mL
0.5 mM	3.57 mL	17.84 mL	35.68 mL
1 mM	1.78 mL	8.92 mL	17.84 mL
5 mM	0.36 mL	1.78 mL	3.57 mL

*The above data is based on the productmolecular weight 560.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.