NVP-BGT226

Catalog No. A11162

NVP-BGT226，新型磷酸肌醇3-激酶/mTOR双重抑制剂，作用于PI3Kα/β/γ，IC50为4 nM/63 nM/38 nM，在体外和体内对人的头颈癌细胞均显示出强大的生长抑制活性。

Technical details

Catalog Num	A11162
M. Wt	650.6
Formula	C28H25F3N6O2.C4H4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1245537-68-1
Synonyms	NVPBGT226, BGT226, BGT-226
SMILES	CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC.C(=C\C(=O)O)\C(=O)O

Biological Activity

NVP-BGT226，新型磷酸肌醇3-激酶/mTOR双重抑制剂，作用于PI3Kα/β/γ，IC50为4 nM/63 nM/38 nM，在体外和体内对人的头颈癌细胞均显示出强大的生长抑制活性。

Targets

mTOR	PI3Kα	PI3Kγ	PI3Kβ
N/A	4 nM	38 nM	63 nM

Solubility *

In vitro (25°C)	DMSO	27 mg/mL (41.5 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.37 mL	76.85 mL	153.7 mL
0.5 mM	3.07 mL	15.37 mL	30.74 mL
1 mM	1.54 mL	7.69 mL	15.37 mL
5 mM	0.31 mL	1.54 mL	3.07 mL

*The above data is based on the productmolecular weight 650.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.