NVP-BGT226
Catalog No. A11162
NVP-BGT226,新型磷酸肌醇3-激酶/mTOR双重抑制剂,作用于PI3Kα/β/γ,IC50为4 nM/63 nM/38 nM,在体外和体内对人的头颈癌细胞均显示出强大的生长抑制活性。
Catalog Num | A11162 |
---|---|
M. Wt | 650.6 |
Formula | C28H25F3N6O2.C4H4O4 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1245537-68-1 |
Synonyms | NVPBGT226, BGT226, BGT-226 |
SMILES | CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC.C(=C\C(=O)O)\C(=O)O |
NVP-BGT226,新型磷酸肌醇3-激酶/mTOR双重抑制剂,作用于PI3Kα/β/γ,IC50为4 nM/63 nM/38 nM,在体外和体内对人的头颈癌细胞均显示出强大的生长抑制活性。
Targets
mTOR | PI3Kα | PI3Kγ | PI3Kβ | |
N/A | 4 nM | 38 nM | 63 nM |
In vitro (25°C) | DMSO | 27 mg/mL (41.5 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 15.37 mL | 76.85 mL | 153.7 mL |
0.5 mM | 3.07 mL | 15.37 mL | 30.74 mL |
1 mM | 1.54 mL | 7.69 mL | 15.37 mL |
5 mM | 0.31 mL | 1.54 mL | 3.07 mL |
*The above data is based on the productmolecular weight 650.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.