RS-127445

Catalog No. A11165

RS-127445是5-羟色胺5-HT2B受体的有效和选择性拮抗剂,相对于密切相关的5-HT2A和5-HT2C受体具有约1000倍的选择性。
  • Takeshi Takayanagi, .et al. Serotonin 5-HT2B receptor antagonism is fundamental for protecting PC12 cells exposed to hydrogen peroxide, Fujita Medical Journal, 2015, 1(1), 1-5, 2015
Catalog Num A11165
M. Wt 281.33
Formula C17H16FN3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 199864-87-4
Synonyms RS127445, MT 500, RS127,445
SMILES CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N.Cl
RS-127445是5-羟色胺5-HT2B受体的有效和选择性拮抗剂,相对于密切相关的5-HT2A和5-HT2C受体具有约1000倍的选择性。
Targets
5-HT2B 5-HT2B
10.4(pIC50)9.5(pKi)
In vitro DMSO 54 mg/mL (191.94 mM)
Water Insoluble
Ethanol 8 mg/mL (28.43 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.55 mL 177.73 mL 355.45 mL
0.5 mM 7.11 mL 35.55 mL 71.09 mL
1 mM 3.55 mL 17.77 mL 35.55 mL
5 mM 0.71 mL 3.55 mL 7.11 mL

*The above data is based on the productmolecular weight 281.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.