SCH 900776 (MK-8776)

Catalog No. A11167

SCH 900776 (MK-8776)是靶向细胞周期检查点激酶1(Chk1)的药物,无细胞试验中IC50为3 nM,比作用于Chk2选择性高500倍。具有潜在的放射增敏和化学增敏活性。
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Catalog Num A11167
M. Wt 376.25
Formula C15H18BrN7
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 891494-63-6
Synonyms SCH-900776, MK-8776, MK8776, MK 8776
SMILES NC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13
SCH 900776 (MK-8776)是靶向细胞周期检查点激酶1(Chk1)的药物,无细胞试验中IC50为3 nM,比作用于Chk2选择性高500倍。具有潜在的放射增敏和化学增敏活性。
In vitro (25°C) DMSO 3 mg/mL (7.97 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% propylene glycol 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.58 mL 132.89 mL 265.78 mL
0.5 mM 5.32 mL 26.58 mL 53.16 mL
1 mM 2.66 mL 13.29 mL 26.58 mL
5 mM 0.53 mL 2.66 mL 5.32 mL

*The above data is based on the productmolecular weight 376.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.