CH5132799

Catalog No. A11169

CH5132799是一种新型的I类PI3K抑制剂，尤其对PI3Kα (IC (50) = 0.014μM) 表现出很强的抑制活性。

Technical details

Catalog Num	A11169
M. Wt	377.42
Formula	C15H19N7O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1007207-67-1
Synonyms	CH-5132799
SMILES	CS(=O)(=O)N1CCC2=C(N=C(N=C21)N3CCOCC3)C4=CN=C(N=C4)N

Biological Activity

CH5132799是一种新型的I类PI3K抑制剂，尤其对PI3Kα (IC (50) = 0.014μM) 表现出很强的抑制活性。

Targets

Target	Value
PI3Kα	IC50: 14nM
PI3Kγ	IC50: 36nM
PI3Kβ	IC50: 0.12μM
PI3Kδ	IC50: 0.50μM
mTOR	IC50: 1.6μM
C2β	IC50: 5.3μM
C2α	IC50: >10μM
Vps34	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	12 mg/mL (31.79 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.5 mL	132.48 mL	264.96 mL
0.5 mM	5.3 mL	26.5 mL	52.99 mL
1 mM	2.65 mL	13.25 mL	26.5 mL
5 mM	0.53 mL	2.65 mL	5.3 mL

*The above data is based on the productmolecular weight 377.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.