PF-03814735

Catalog No. A11171

PF-03814735是一种新颖,有效且可逆的Aurora A/B抑制剂,IC50为0.8 nM/5 nM,对Flt3,FAK,TrkA的效力较低,对Met和FGFR1的活性最低。
Catalog Num A11171
M. Wt 474.48
Formula C23H25F3N6O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 942487-16-3
Synonyms PF03814735
SMILES CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CCC5)C(F)(F)F
PF-03814735是一种新颖,有效且可逆的Aurora A/B抑制剂,IC50为0.8 nM/5 nM,对Flt3,FAK,TrkA的效力较低,对Met和FGFR1的活性最低。
Targets
Aurora A Aurora B FLT1 FAK TrkA
0.8 nM5 nM10 nM22 nM30 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.08 mL 105.38 mL 210.76 mL
0.5 mM 4.22 mL 21.08 mL 42.15 mL
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL

*The above data is based on the productmolecular weight 474.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.