PF-03814735
Catalog No. A11171
PF-03814735是一种新颖,有效且可逆的Aurora A/B抑制剂,IC50为0.8 nM/5 nM,对Flt3,FAK,TrkA的效力较低,对Met和FGFR1的活性最低。
Catalog Num | A11171 |
---|---|
M. Wt | 474.48 |
Formula | C23H25F3N6O2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 942487-16-3 |
Synonyms | PF03814735 |
SMILES | CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CCC5)C(F)(F)F |
PF-03814735是一种新颖,有效且可逆的Aurora A/B抑制剂,IC50为0.8 nM/5 nM,对Flt3,FAK,TrkA的效力较低,对Met和FGFR1的活性最低。
Targets
Aurora A | Aurora B | FLT1 | FAK | TrkA |
0.8 nM | 5 nM | 10 nM | 22 nM | 30 nM |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.08 mL | 105.38 mL | 210.76 mL |
0.5 mM | 4.22 mL | 21.08 mL | 42.15 mL |
1 mM | 2.11 mL | 10.54 mL | 21.08 mL |
5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
*The above data is based on the productmolecular weight 474.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.