Nepicastat HCl
Catalog No. A11172
Nepicastat HCl是多巴胺β-羟化酶的抑制剂,该酶催化多巴胺向去甲肾上腺素的转化。
- Melina C Acosta, .et al. Acute inhibition of dopamine β-hydroxylase attenuates behavioral responses to pups in adult virgin California mice (Peromyscus californicus), Horm Behav, 2022, Jan;137:105086 PMID: 34808463
Catalog Num | A11172 |
---|---|
M. Wt | 331.81 |
Formula | C14H15F2N3S.HCl |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 170151-24-3 |
Synonyms | RS-25560-197, SYN117 |
SMILES | C1CC2=C(C=C(C=C2C[C@H]1N3C(=CNC3=S)CN)F)F.Cl |
Nepicastat HCl是多巴胺β-羟化酶的抑制剂,该酶催化多巴胺向去甲肾上腺素的转化。
Targets
Bovine dopamine-beta-hydroxylase | Human dopamine-beta-hydroxylase | |||
8.5 nM | 9 nM |
In vitro (25°C) | DMSO | 59 mg/mL (177.8 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 1% CMC Na | 19 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 30.14 mL | 150.69 mL | 301.38 mL |
0.5 mM | 6.03 mL | 30.14 mL | 60.28 mL |
1 mM | 3.01 mL | 15.07 mL | 30.14 mL |
5 mM | 0.6 mL | 3.01 mL | 6.03 mL |
*The above data is based on the productmolecular weight 331.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.