Nepicastat HCl

Catalog No. A11172

Nepicastat HCl是多巴胺β-羟化酶的抑制剂,该酶催化多巴胺向去甲肾上腺素的转化。
  • Melina C Acosta, .et al. Acute inhibition of dopamine β-hydroxylase attenuates behavioral responses to pups in adult virgin California mice (Peromyscus californicus), Horm Behav, 2022, Jan;137:105086 PMID: 34808463
Catalog Num A11172
M. Wt 331.81
Formula C14H15F2N3S.HCl
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 170151-24-3
Synonyms RS-25560-197, SYN117
SMILES C1CC2=C(C=C(C=C2C[C@H]1N3C(=CNC3=S)CN)F)F.Cl
Nepicastat HCl是多巴胺β-羟化酶的抑制剂,该酶催化多巴胺向去甲肾上腺素的转化。
Targets
Bovine dopamine-beta-hydroxylase Human dopamine-beta-hydroxylase
8.5 nM9 nM
In vitro (25°C) DMSO 59 mg/mL (177.8 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% CMC Na 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.14 mL 150.69 mL 301.38 mL
0.5 mM 6.03 mL 30.14 mL 60.28 mL
1 mM 3.01 mL 15.07 mL 30.14 mL
5 mM 0.6 mL 3.01 mL 6.03 mL

*The above data is based on the productmolecular weight 331.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.