NSC-207895 (XI-006)

Catalog No. A11179

NSC-207895 (XI-006)是细胞可渗透的苯并呋喃化合物，可通过抑制MDMX启动子转录活性（IC50 = 2.5 ?M，下调MCF-7，LNCaP和A549细胞中的p53负调节剂MDMX蛋白水平（1至10 ?M，持续16至24 h）），导致增强的p53稳定和激活。

Technical details

Catalog Num	A11179
M. Wt	279.25
Formula	C11H13N5O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	58131-57-0
Synonyms	NSC207895
SMILES	CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-]

Biological Activity

Targets

p53	MDMX
N/A	2.5 μM

Solubility *

In vitro	DMSO	0.39 mg/mL (1.39 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.81 mL	179.05 mL	358.1 mL
0.5 mM	7.16 mL	35.81 mL	71.62 mL
1 mM	3.58 mL	17.91 mL	35.81 mL
5 mM	0.72 mL	3.58 mL	7.16 mL

*The above data is based on the productmolecular weight 279.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.