WAY-362450

Catalog No. A11186

WAY-362450是一种高效，选择性和口服可生物利用的法呢类X受体（FXR）激动剂（EC50：4 nM，eff = 149％）。

Product Citations

Dong-Hyun Kim, .et al. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD, Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
Dong-Hyun Kim, .et al. Src-mediated crosstalk between FXR and YAP protects against renal fibrosis, FASEB J, 2019, Jul 12:fj201900325R PMID: 31298930

Technical details

Catalog Num	A11186
M. Wt	438.47
Formula	C25H24F2N2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	629664-81-9
Synonyms	WAY362450, XL335
SMILES	CC(C)OC(=O)C1=CN(CC(C2=C1NC3=CC=CC=C32)(C)C)C(=O)C4=CC(=C(C=C4)F)F

Biological Activity

WAY-362450是一种高效，选择性和口服可生物利用的法呢类X受体（FXR）激动剂（EC50：4 nM，eff = 149％）。

Targets

FXR
4 nM(EC50)

Solubility *

In vitro (25°C)	DMSO	Warmed: 31 mg/mL (70.7 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (4.56 mM)
In vivo	NMP+PEG300 (10+90, v+v)	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.81 mL	114.03 mL	228.07 mL
0.5 mM	4.56 mL	22.81 mL	45.61 mL
1 mM	2.28 mL	11.4 mL	22.81 mL
5 mM	0.46 mL	2.28 mL	4.56 mL

*The above data is based on the productmolecular weight 438.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.