MK-0752
Catalog No. A11194
MK-0752抑制Notch信号通路,这可能会导致Notch信号通路被过度激活的肿瘤细胞诱导生长停滞和凋亡。
Catalog Num | A11194 |
---|---|
M. Wt | 442.9 |
Formula | C21H21ClF2O4S |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 471905-41-6 |
Synonyms | MK0752 |
SMILES | C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl |
MK-0752抑制Notch信号通路,这可能会导致Notch信号通路被过度激活的肿瘤细胞诱导生长停滞和凋亡。
In vitro (25°C) | DMSO | 85 mg/mL (191.91 mM) | |
Water | Insoluble | ||
Ethanol | 43 mg/mL (97.08 mM) | ||
In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.58 mL | 112.89 mL | 225.78 mL |
0.5 mM | 4.52 mL | 22.58 mL | 45.16 mL |
1 mM | 2.26 mL | 11.29 mL | 22.58 mL |
5 mM | 0.45 mL | 2.26 mL | 4.52 mL |
*The above data is based on the productmolecular weight 442.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.