A 922500

Catalog No. A11199

922500是一种二酰基甘油酰基转移酶1(DGAT-1)抑制剂(人和小鼠DGAT-1的IC50值分别为7和24 nM)。
  • SIFEI HAN, .et al. Constitutive Triglyceride Turnover into the Mesenteric Lymph Is Unable to Support Efficient Lymphatic Transport of a Biomimetic Triglyceride Prodrug, J Pharm Sci, 2016, Feb;105(2):786-796 PMID: 6540595
Catalog Num A11199
M. Wt 428.48
Formula C26H24N2O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 959122-11-3
Synonyms DGAT-1 Inhibitor 4a, A-922500, A922500
SMILES C1C[C@H]([C@@H](C1)C(=O)O)C(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)NC(=O)NC4=CC=CC=C4
922500是一种二酰基甘油酰基转移酶1(DGAT-1)抑制剂(人和小鼠DGAT-1的IC50值分别为7和24 nM)。
Targets
human DGAT-1 mouse DGAT-1 DGAT-2
7 nM24 nM53 μM
In vitro (25°C) DMSO 83 mg/mL (193.7 mM)
Water Insoluble
Ethanol Insoluble
In vivo 15% Captisol 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.69 mL 233.38 mL
0.5 mM 4.67 mL 23.34 mL 46.68 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

*The above data is based on the productmolecular weight 428.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.