A 922500
Catalog No. A11199
922500是一种二酰基甘油酰基转移酶1(DGAT-1)抑制剂(人和小鼠DGAT-1的IC50值分别为7和24 nM)。
- SIFEI HAN, .et al. Constitutive Triglyceride Turnover into the Mesenteric Lymph Is Unable to Support Efficient Lymphatic Transport of a Biomimetic Triglyceride Prodrug, J Pharm Sci, 2016, Feb;105(2):786-796 PMID: 6540595
Catalog Num | A11199 |
---|---|
M. Wt | 428.48 |
Formula | C26H24N2O4 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 959122-11-3 |
Synonyms | DGAT-1 Inhibitor 4a, A-922500, A922500 |
SMILES | C1C[C@H]([C@@H](C1)C(=O)O)C(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)NC(=O)NC4=CC=CC=C4 |
922500是一种二酰基甘油酰基转移酶1(DGAT-1)抑制剂(人和小鼠DGAT-1的IC50值分别为7和24 nM)。
Targets
human DGAT-1 | mouse DGAT-1 | DGAT-2 | ||
7 nM | 24 nM | 53 μM |
In vitro (25°C) | DMSO | 83 mg/mL (193.7 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 15% Captisol | 19 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.34 mL | 116.69 mL | 233.38 mL |
0.5 mM | 4.67 mL | 23.34 mL | 46.68 mL |
1 mM | 2.33 mL | 11.67 mL | 23.34 mL |
5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
*The above data is based on the productmolecular weight 428.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.