BMS-806 (BMS 378806)

Catalog No. A11201

BMS-806，也称为BMS-378806，选择性抑制HIV-1 gp120与CD4受体结合，EC50为0.85-26.5 nM。通过阻止HIV进入人体细胞而发挥作用。可阻断宿主细胞CD4与病毒gp120蛋白的结合，因此可抑制HIV-1感染的第一步。

Technical details

Catalog Num	A11201
M. Wt	406.43
Formula	C22H22N4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	357263-13-9
Synonyms	BMS806, BMS378806, BMS-378806
SMILES	C[C@@H]1CN(CCN1C(=O)C(=O)C2=CNC3=NC=CC(=C23)OC)C(=O)C4=CC=CC=C4

Solubility *

In vitro (25°C)	DMSO	73 mg/mL (179.61 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (7.38 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.6 mL	123.02 mL	246.04 mL
0.5 mM	4.92 mL	24.6 mL	49.21 mL
1 mM	2.46 mL	12.3 mL	24.6 mL
5 mM	0.49 mL	2.46 mL	4.92 mL

*The above data is based on the productmolecular weight 406.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

BMS-806 (BMS 378806)

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions