GW3965 HCl

Catalog No. A11204

GW3965 HCl是一种选择性的口服活性肝X受体（LXR）完全激动剂。

Product Citations

Mohácsik P, .et al. A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action, Endocrinology, 2018, Feb 1;159(2):1159-1171 PMID: 29253128
Pencheva N, .et al. Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation., Cell., 2014, 156(5):986-1001 PMID: 24581497
Bin Dong, .et al. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway, J Lipid Res., 2013, May; 54(5): 1241-1254. PMID: 23427282

Technical details

Catalog Num	A11204
M. Wt	618.51
Formula	C33H31ClF3NO3.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	405911-17-3
Synonyms	GW-3965
SMILES	C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl

Biological Activity

GW3965 HCl是一种选择性的口服活性肝X受体（LXR）完全激动剂。

Targets

hLXRβ (Cell-free assay)	LXRα/SRC1?LiSA (Cell-free assay)	hLXRα (Cell-free assay)
30 nM(EC50)	125 nM(EC50)	190 nM(EC50)

Solubility *

In vitro	DMSO	Warmed: 16 mg/mL (25.86 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.17 mL	80.84 mL	161.68 mL
0.5 mM	3.23 mL	16.17 mL	32.34 mL
1 mM	1.62 mL	8.08 mL	16.17 mL
5 mM	0.32 mL	1.62 mL	3.23 mL

*The above data is based on the productmolecular weight 618.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.