PP121

Catalog No. A11207

PP121是一种作用于PDGFR，Hck，mTOR，VEGFR2，Src和Abl的多靶点抑制剂，IC50分别为2 nM，8 nM，10 nM，12 nM，14 nM和18 nM，也抑制DNA-PK，IC50为60 nM。

Technical details

Catalog Num	A11207
M. Wt	319.36
Formula	C17H17N7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1092788-83-4
Synonyms	PP-121
SMILES	C1CCC(C1)N2C3=C(C(=N2)C4=CN=C5C(=C4)C=CN5)C(=NC=N3)N

Biological Activity

PP121是一种作用于PDGFR，Hck，mTOR，VEGFR2，Src和Abl的多靶点抑制剂，IC50分别为2 nM，8 nM，10 nM，12 nM，14 nM和18 nM，也抑制DNA-PK，IC50为60 nM。

Targets

Target	Value
PDGFR	IC50: 2nM
Hck	IC50: 8nM
VEGFR	IC50: 12nM
mTOR	IC50: 13nM
Src	IC50: 14nM
Abl	IC50: 18nM
p110α	IC50: 52nM
DNA-PK	IC50: 60nM
p110δ	IC50: 150nM
EphB4	IC50: 190nM
EGFR	IC50: 260nM
p110γ	IC50: 1.1μM
p110β	IC50: 1.4μM

Solubility *

In vitro	DMSO	63 mg/mL (197.27 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (6.26 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.31 mL	156.56 mL	313.13 mL
0.5 mM	6.26 mL	31.31 mL	62.63 mL
1 mM	3.13 mL	15.66 mL	31.31 mL
5 mM	0.63 mL	3.13 mL	6.26 mL

*The above data is based on the productmolecular weight 319.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.