Kenpaullone

Catalog No. A11220

Kenpaullone是CDK1/细胞周期蛋白B（IC 50 = 400 nM），CDK2/细胞周期蛋白A（IC 50 = 680nM），CDK5（IC 50 = 850nM）的有效抑制剂，对其他激酶的作用要小得多。

Product Citations

Katelyn M Green, .et al. High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation, J Biol Chem, 2019, jbc.RA119.009951

Technical details

Catalog Num	A11220
M. Wt	327.2
Formula	C16H11BrN2O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	142273-20-9
Synonyms
SMILES	C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br

Biological Activity

Kenpaullone是CDK1/细胞周期蛋白B（IC 50 = 400 nM），CDK2/细胞周期蛋白A（IC 50 = 680nM），CDK5（IC 50 = 850nM）的有效抑制剂，对其他激酶的作用要小得多。

Targets

Target	Value
GSK-3β	IC50: 0.23μM
CDK1/CyclinB	IC50: 0.4μM
CDK2/CyclinA	IC50: 0.68μM
CDK5/p35	IC50: 0.85μM
CDK2/CyclinE	IC50: 7.5μM
ERK2	IC50: 9μM
c-Src	IC50: 15μM
CaseinKinase2	IC50: 20μM
ERK1	IC50: 20μM

Solubility *

In vitro (25°C)	DMSO	58 mg/mL (177.27 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+50% PEG 300+5% Tween 80+ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.56 mL	152.81 mL	305.62 mL
0.5 mM	6.11 mL	30.56 mL	61.12 mL
1 mM	3.06 mL	15.28 mL	30.56 mL
5 mM	0.61 mL	3.06 mL	6.11 mL

*The above data is based on the productmolecular weight 327.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.