Linagliptin (BI-1356)

Catalog No. A11224

Linagliptin (BI-1356)是DPP-4抑制剂，是一种降解肠降血糖素激素胰高血糖素样肽1（GLP-1）和葡萄糖依赖性促胰岛素多肽（GIP）的酶。

Technical details

Catalog Num	A11224
M. Wt	472.5
Formula	C25H28N8O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	668270-12-0
Synonyms	BI-1356,Tradjenta,Trajenta
SMILES	CC#CCN1C2=C(N=C1N3CCC[C@H](C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C

Biological Activity

Linagliptin (BI-1356)是DPP-4抑制剂，是一种降解肠降血糖素激素胰高血糖素样肽1（GLP-1）和葡萄糖依赖性促胰岛素多肽（GIP）的酶。

Targets

DPP-4
1 nM

Solubility *

In vitro (25°C)	DMSO	16 mg/mL (33.85 mM)
	Water	Insoluble
	Ethanol	1 mg/mL (2.11 mM)
In vivo	0.5% hydroxyethyl cellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.16 mL	105.82 mL	211.64 mL
0.5 mM	4.23 mL	21.16 mL	42.33 mL
1 mM	2.12 mL	10.58 mL	21.16 mL
5 mM	0.42 mL	2.12 mL	4.23 mL

*The above data is based on the productmolecular weight 472.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.