PF 573228

Catalog No. A11235

PF 573228是一种有效和选择性的粘着斑激酶（FAK）抑制剂（IC50 = 4 nM）。

Product Citations

Izumi D, .et al. CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer, Int J Cancer, 2016, Mar 1;138(5):1207-19 PMID: 26414794
Aya Yokota-Nakatsuma, .et al. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties, Sci Rep, 2016, 6: 37914 PMID: 27897208

Technical details

Catalog Num	A11235
M. Wt	491.5
Formula	C22H20F3N5O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	869288-64-2
Synonyms	PF-573228, PF573228
SMILES	CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4

Biological Activity

PF 573228是一种有效和选择性的粘着斑激酶（FAK）抑制剂（IC50 = 4 nM）。

Targets

FAK (Cell-free assay)
4 nM

Solubility *

In vitro (25°C)	DMSO	24 mg/mL (48.83 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+2% Tween 80+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.35 mL	101.73 mL	203.46 mL
0.5 mM	4.07 mL	20.35 mL	40.69 mL
1 mM	2.03 mL	10.17 mL	20.35 mL
5 mM	0.41 mL	2.03 mL	4.07 mL

*The above data is based on the productmolecular weight 491.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.