GDC-0068 (Ipatasertib, RG-7440)

Catalog No. A11246

GDC-0068 (Ipatasertib,RG-7440)是一种选择性的,具有ATP竞争性的pan-Akt抑制剂,在无细胞试验中,其靶向Akt1、2和3的IC50值分别为5、18和8 nM。
Catalog Num A11246
M. Wt 458
Formula C24H32ClN5O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1001264-89-6
Synonyms GDC0068, RG7440
SMILES C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNC(C)C)C4=CC=C(C=C4)Cl)O
GDC-0068 (Ipatasertib,RG-7440)是一种选择性的,具有ATP竞争性的pan-Akt抑制剂,在无细胞试验中,其靶向Akt1、2和3的IC50值分别为5、18和8 nM。
Targets
Akt1 (Cell-free assay) Akt3 (Cell-free assay) Akt2 (Cell-free assay)
5 nM8 nM18 nM
In vitro DMSO 91 mg/mL (198.69 mM)
Water Insoluble
Ethanol 91 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.83 mL 109.17 mL 218.34 mL
0.5 mM 4.37 mL 21.83 mL 43.67 mL
1 mM 2.18 mL 10.92 mL 21.83 mL
5 mM 0.44 mL 2.18 mL 4.37 mL

*The above data is based on the productmolecular weight 458. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.