XL-888
Catalog No. A11251
XL888是口服可生物利用的,具有ATP竞争性的小分子热休克蛋白90(Hsp90)抑制剂,IC50为24 nM。具有潜在的抗肿瘤活性。
Catalog Num | A11251 |
---|---|
M. Wt | 503.63 |
Formula | C29H37N5O3 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1149705-71-4 |
Synonyms | XL888; XL-888; XL 888 |
SMILES | CCC(C)NC1=CC(=C(C=C1C(=O)N)C)C(=O)NC2C[C@H]3CC[C@@H](C2)N3C4=NC=C(C=C4)C(=O)C5CC5 |
XL888是口服可生物利用的,具有ATP竞争性的小分子热休克蛋白90(Hsp90)抑制剂,IC50为24 nM。具有潜在的抗肿瘤活性。
Targets
HSP90 | ||||
24 nM |
In vitro (25°C) | DMSO | 99 mg/mL (196.56 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 19.86 mL | 99.28 mL | 198.56 mL |
0.5 mM | 3.97 mL | 19.86 mL | 39.71 mL |
1 mM | 1.99 mL | 9.93 mL | 19.86 mL |
5 mM | 0.4 mL | 1.99 mL | 3.97 mL |
*The above data is based on the productmolecular weight 503.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.