EMD-1214063

Catalog No. A11257

EMD-1214063是MET酪氨酸激酶的抑制剂，IC50为4 nM，作用于c-Met比作用于IRAK4， TrkA， Axl， IRAK1和Mer选择性高200倍以上。具有潜在的抗肿瘤活性。它与MET酪氨酸激酶结合并破坏MET信号转导途径，这可能在过表达该激酶的肿瘤细胞中诱导凋亡。

Technical details

Catalog Num	A11257
M. Wt	492.6
Formula	C29H28N6O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1100598-32-0
Synonyms	EMD1214063
SMILES	CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC(=CC=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N

Biological Activity

Targets

Target	Value
c-Met	IC50: 4nM
IRAK4	IC50: 615nM
TrkA	IC50: 1.017μM
Axl	IC50: 1.566μM
IRAK1	IC50: 2.037μM
Mer	IC50: 2.272μM
TrkB	IC50: 5.716μM
RON	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 4 mg/mL (8.12 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+corn oil	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.3 mL	101.5 mL	203 mL
0.5 mM	4.06 mL	20.3 mL	40.6 mL
1 mM	2.03 mL	10.15 mL	20.3 mL
5 mM	0.41 mL	2.03 mL	4.06 mL

*The above data is based on the productmolecular weight 492.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.