Refametinib

Catalog No. A11264

Refametinib是一种有效的，ATP非竞争性和高度选择性的MEK1和MEK2抑制剂，IC50分别为19 nM和47 nM。

Technical details

Catalog Num	A11264
M. Wt	572.34
Formula	C19H20F3IN2O5S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	923032-37-5
Synonyms	BAY 869766,RDEA119, Bay 86-9766
SMILES	COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)C[C@@H](CO)O)NC3=C(C=C(C=C3)I)F)F)F

Biological Activity

Refametinib是一种有效的，ATP非竞争性和高度选择性的MEK1和MEK2抑制剂，IC50分别为19 nM和47 nM。

Targets

MEK1	MEK2
19 nM	47 nM

Solubility *

In vitro	DMSO	95 mg/mL (165.98 mM)
	Water	Insoluble
	Ethanol	95 mg/mL (165.98 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.47 mL	87.36 mL	174.72 mL
0.5 mM	3.49 mL	17.47 mL	34.94 mL
1 mM	1.75 mL	8.74 mL	17.47 mL
5 mM	0.35 mL	1.75 mL	3.49 mL

*The above data is based on the productmolecular weight 572.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.