PR-171 (Carfilzomib)

Catalog No. A11278

PR-171 (Carfilzomib)是四肽环氧酮和选择性蛋白酶体抑制剂。它是环氧霉素的类似物。

Product Citations

Ori Kalid, .et al. PTX80, A Novel Compound Targeting the Autophagy Receptor p62/SQSTM1 for Treatment of Cancer, Chem Biol Drug Des, 2022, Mar 24 PMID: 35322538
Abbas Rahdar, .et al. Pluronic F127/carfilzomib-based nanomicelles as promising nanocarriers: synthesis, characterization, biological, and in silico evaluations, Journal of Molecular Liquids, 2022, 346: 118271
Sadegh Zarei, .et al. Carfilzomib Induces Drug Resistance in A2780 Ovarian Cancer Cells Through p53-Dependent and Caspase-3 Independent Pathways, J Appl Biotechnol Rep, 2019, June;6(2):45-49
Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Technical details

Catalog Num	A11278
M. Wt	719.9
Formula	C40H57N5O7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	868540-17-4
Synonyms	PR-171-007
SMILES	CC(C)C[C@@H](C(=O)[C@]1(CO1)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4

Biological Activity

PR-171 (Carfilzomib)是四肽环氧酮和选择性蛋白酶体抑制剂。它是环氧霉素的类似物。

Targets

Proteasome (ANBL-6 cells)
5 nM

Solubility *

In vitro (25°C)	DMSO	46 mg/mL (63.89 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2%Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.89 mL	69.45 mL	138.91 mL
0.5 mM	2.78 mL	13.89 mL	27.78 mL
1 mM	1.39 mL	6.95 mL	13.89 mL
5 mM	0.28 mL	1.39 mL	2.78 mL

*The above data is based on the productmolecular weight 719.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.