AKT inhibitor VIII (AKTI-1/2)

Catalog No. A11286

AKT inhibitor VIII (AKTI-1/2)是一种细胞可渗透且可逆的喹喔啉化合物，在体外激酶测定中，该化合物有效和选择性地抑制Akt1/Akt2活性（对于Akt1，Akt2和Akt3，IC50分别为58 nM，210 nM和2.12μM）。

Product Citations

Bjune K, .et al. Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms, PLoS One, 2019, Jun 19;14(6):e0218537 PMID: 31216345
Hoshiba T, .et al. Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels: Mechanism of 5-fluorouracil resistance in colorectal tumor cells, Biochim Biophys Acta, 2016, Nov;1863(11):2749-2757 PMID: 27558478

Technical details

Catalog Num	A11286
M. Wt	551.6
Formula	C34H29N7O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	612847-09-3
Synonyms
SMILES	C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7

Biological Activity

Targets

Akt1	Akt2	Akt3
58 nM	210 nM	2119 nM

Solubility *

In vitro	DMSO	19 mg/mL (34.44 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.13 mL	90.65 mL	181.29 mL
0.5 mM	3.63 mL	18.13 mL	36.26 mL
1 mM	1.81 mL	9.06 mL	18.13 mL
5 mM	0.36 mL	1.81 mL	3.63 mL

*The above data is based on the productmolecular weight 551.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.