AZD2014 (Vistusertib)

Catalog No. A11303

Vistusertib (AZD2014)是一种新型mTOR抑制剂，无细胞试验中IC50为2.8 nM；对多种PI3K亚型(α/β/γ/δ)具有较高选择性。浓度为1 μM时，对大多数激酶无或有微弱结合力。

Product Citations

Shuhang Dai, .et al. Calcium/calmodulin-dependent protein kinase kinase 2 mediates pleiotropic effects of epidermal growth factor in cancer cells, Biochim Biophys Acta Mol Cell Res, 2022, Jul;1869(7):119252 PMID: 35271909

Technical details

Catalog Num	A11303
M. Wt	462.5
Formula	C25H30N6O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1009298-59-2
Synonyms	AZD-2014
SMILES	C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOC[C@@H]5C

Biological Activity

Targets

mTOR (Cell-free assay)	P-Akt (S473) (Cell-free assay)	pS6 (S235/236) (Cell-free assay)
2.8 nM	80 nM	200 nM

Solubility *

In vitro (25°C)	DMSO	32 mg/mL (69.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.62 mL	108.11 mL	216.22 mL
0.5 mM	4.32 mL	21.62 mL	43.24 mL
1 mM	2.16 mL	10.81 mL	21.62 mL
5 mM	0.43 mL	2.16 mL	4.32 mL

*The above data is based on the productmolecular weight 462.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.