Skepinone-L

Catalog No. A11321

Skepinone-L是选择性p38丝裂原活化蛋白激酶抑制剂。

Product Citations

Ramona Rudalska, etc. In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer. Nat Med. 2014 Oct; 20(10): 1138–1146.

Technical details

Catalog Num	A11321
M. Wt	425.42
Formula	C24H21F2NO4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1221485-83-1
Synonyms	Skepinone L
SMILES	C1CC2=C(C=CC(=C2)NC3=C(C=C(C=C3)F)F)C(=O)C4=C1C=CC(=C4)OC[C@@H](CO)O

Biological Activity

Skepinone-L是选择性p38丝裂原活化蛋白激酶抑制剂。

Targets

p38α
5 nM

Solubility *

In vitro (25°C)	DMSO	81 mg/mL (190.4 mM)
	Water	Insoluble
	Ethanol	81 mg/mL (190.4 mM)
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.51 mL	117.53 mL	235.06 mL
0.5 mM	4.7 mL	23.51 mL	47.01 mL
1 mM	2.35 mL	11.75 mL	23.51 mL
5 mM	0.47 mL	2.35 mL	4.7 mL

*The above data is based on the productmolecular weight 425.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.