Bardoxolone methyl (RTA 402)

Catalog No. A11323

Bardoxolone甲基是口服的一流的合成三萜类化合物。它是Nrf2途径的诱导剂，可以抑制氧化应激和炎症。

Product Citations

Nakamura S, .et al. Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability, Invest Ophthalmol Vis Sci, 2019, 60: 1943-1952
Hisamichi M, .et al. Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone- and salt-induced renal injury, Hypertens Res, 2018, Jan;41(1):8-17 PMID: 28978980
Takahiko Imai, .et al. Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under anticoagulation, Neurobiol Dis, 2016, May;89:136-46 PMID: 26850917
Takagi T, .et al. Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury., Free Radic Biol Med., 2014, 72:124-33 PMID: 24746614

Technical details

Catalog Num	A11323
M. Wt	505.7
Formula	C32H43NO4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	218600-53-4
Synonyms	NSC 713200, CDDO-methyl ester
SMILES	C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC

Biological Activity

Bardoxolone甲基是口服的一流的合成三萜类化合物。它是Nrf2途径的诱导剂，可以抑制氧化应激和炎症。

Targets

IKK (Cell-free assay)

Solubility *

In vitro (25°C)	DMSO	21 mg/mL (41.52 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4%DMSO+30% PEG300+5% Tween+61%ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.77 mL	98.87 mL	197.75 mL
0.5 mM	3.95 mL	19.77 mL	39.55 mL
1 mM	1.98 mL	9.89 mL	19.77 mL
5 mM	0.4 mL	1.98 mL	3.95 mL

*The above data is based on the productmolecular weight 505.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.