CZC24832

Catalog No. A11363

CZC24832是一种有效的选择性PI3Kγ抑制剂(在PI3Kγ依赖性fMLP诱导的中性粒细胞迁移试验中IC50 = 1.0 μM)。

Product Citations

Yoshihiro Umezawa, .et al. Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1), J Biol Chem, 2017, Dec 1; 292(48): 19639-19655 PMID: 28974577

Technical details

Catalog Num	A11363
M. Wt	364.4
Formula	C15H17FN6O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1159824-67-5
Synonyms	CZC 24832, CZC-24832
SMILES	CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)N)C(=C2)F

Biological Activity

CZC24832是一种有效的选择性PI3Kγ抑制剂(在PI3Kγ依赖性fMLP诱导的中性粒细胞迁移试验中IC50 = 1.0 μM)。

Targets

PI3Kγ	PI3Kβ	PI3Kδ
27 nM	1.1 μM	8.2 μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 5 mg/mL (13.72 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.44 mL	137.21 mL	274.42 mL
0.5 mM	5.49 mL	27.44 mL	54.88 mL
1 mM	2.74 mL	13.72 mL	27.44 mL
5 mM	0.55 mL	2.74 mL	5.49 mL

*The above data is based on the productmolecular weight 364.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.