E-7050 (Golvatinib)

Catalog No. A11396

E-7050 (Golvatinib)是具有潜在抗肿瘤活性的c-Met(肝细胞生长因子受体)和VEGFR-2(血管内皮生长因子受体-2)酪氨酸激酶的口服生物可利用双重激酶抑制剂。

Technical details

Catalog Num	A11396
M. Wt	633.69
Formula	C33H37F2N7O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	928037-13-2
Synonyms
SMILES	CN1CCN(CC1)C2CCN(CC2)C(=O)NC3=NC=CC(=C3)OC4=CC(=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F

Biological Activity

E-7050 (Golvatinib)是具有潜在抗肿瘤活性的c-Met(肝细胞生长因子受体)和VEGFR-2(血管内皮生长因子受体-2)酪氨酸激酶的口服生物可利用双重激酶抑制剂。

Targets

c-Met	VEGFR2
14 nM	16 nM

Solubility *

In vitro (25°C)	DMSO	18 mg/mL (28.4 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.78 mL	78.9 mL	157.81 mL
0.5 mM	3.16 mL	15.78 mL	31.56 mL
1 mM	1.58 mL	7.89 mL	15.78 mL
5 mM	0.32 mL	1.58 mL	3.16 mL

*The above data is based on the productmolecular weight 633.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.