Evacetrapib (LY2484595)

Catalog No. A11397

Evacetrapib (LY2484595)是一种强效选择性CETP抑制剂，IC50为5.5 nM，可在不增加醛固酮或血压的情况下升高HDL胆固醇。

Technical details

Catalog Num	A11397
M. Wt	638.65
Formula	C31H36F6N6O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1186486-62-3
Synonyms	LY2484595, LY-2484595, LY 2484595
SMILES	CC1=CC(=C2C(=C1)[C@H](CCCN2CC3CCC(CC3)C(=O)O)N(CC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C5=NN(N=N5)C)C

Biological Activity

Evacetrapib (LY2484595)是一种强效选择性CETP抑制剂，IC50为5.5 nM，可在不增加醛固酮或血压的情况下升高HDL胆固醇。

Targets

CETP
5.5 nM

Solubility *

In vitro (25°C)	DMSO	11 mg/mL (17.22 mM)
	Water	Insoluble
	Ethanol	11 mg/mL (17.22 mM)
In vivo	15% Captisol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.66 mL	78.29 mL	156.58 mL
0.5 mM	3.13 mL	15.66 mL	31.32 mL
1 mM	1.57 mL	7.83 mL	15.66 mL
5 mM	0.31 mL	1.57 mL	3.13 mL

*The above data is based on the productmolecular weight 638.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.