PA-824 (Pretomanid)

Catalog No. A11401

PA-824 (Pretomanid)是一种实验性抗结核药物，MIC为<1 μg/mL。

Product Citations

Wang X, .et al. Antitubercular Triazines: Optimization and Intrabacterial Metabolism, Cell Chem Biol, 2019, Nov 7. pii: S2451-9456(19)30355-1 PMID: 31711854
Alexandre López-Gavín, .et al. In vitro activity against Mycobacterium tuberculosis of levofloxacin, moxifloxacin and UB-8902 in combination with clofazimine and pretomanid., Int J Antimicrob Agents., 2015, Nov;46(5):582-5 PMID: 26421981

Technical details

Catalog Num	A11401
M. Wt	359.3
Formula	C14H12F3N3O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	187235-37-6
Synonyms	PA824
SMILES	C1[C@@H](COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F

Biological Activity

PA-824 (Pretomanid)是一种实验性抗结核药物，MIC为<1 μg/mL。

Targets

tuberculosis

Solubility *

In vitro (25°C)	DMSO	64 mg/mL (178.14 mM)
	Water	Insoluble
	Ethanol	14 mg/mL (38.96 mM)
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.83 mL	139.16 mL	278.32 mL
0.5 mM	5.57 mL	27.83 mL	55.66 mL
1 mM	2.78 mL	13.92 mL	27.83 mL
5 mM	0.56 mL	2.78 mL	5.57 mL

*The above data is based on the productmolecular weight 359.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.