MK-8245

Catalog No. A11403

MK-8245是肝脏靶向的硬脂酰CoA去饱和酶（SCD）抑制剂。MK-8245可用于治疗糖尿病和血脂异常。

Product Citations

Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467

Technical details

Catalog Num	A11403
M. Wt	467.3
Formula	C17H16BrFN6O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1030612-90-8, 1030612-87-3
Synonyms	MK8245
SMILES	C1CN(CCC1OC2=C(C=CC(=C2)F)Br)C3=NOC(=C3)C4=NN(N=N4)CC(=O)O

Biological Activity

MK-8245是肝脏靶向的硬脂酰CoA去饱和酶（SCD）抑制剂。MK-8245可用于治疗糖尿病和血脂异常。

Targets

SCD1 (human)	SCD1 (rat)	SCD1 (mouse)
1 nM	3 nM	3 nM

Solubility *

In vitro (25°C)	DMSO	89 mg/mL (190.47 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% CMC+0.5% Tween-80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.4 mL	107 mL	214 mL
0.5 mM	4.28 mL	21.4 mL	42.8 mL
1 mM	2.14 mL	10.7 mL	21.4 mL
5 mM	0.43 mL	2.14 mL	4.28 mL

*The above data is based on the productmolecular weight 467.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.