GNF 2

Catalog No. A11439

GNF 2是一种Bcr-abl抑制剂，在表达Bcr-abl的细胞中抑制增殖并诱导凋亡。

Technical details

Catalog Num	A11439
M. Wt	374.3
Formula	C18H13F3N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	778270-11-4
Synonyms	GNF2,GNF-2
SMILES	C1=CC(=CC(=C1)C(=O)N)C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F

Biological Activity

GNF 2是一种Bcr-abl抑制剂，在表达Bcr-abl的细胞中抑制增殖并诱导凋亡。

Targets

Bcr-Abl (SUP-B15 cell line)	Bcr-Abl (K562 cell line)
268 nM	273 nM

Solubility *

In vitro	DMSO	67 mg/mL (178.99 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.72 mL	133.58 mL	267.17 mL
0.5 mM	5.34 mL	26.72 mL	53.43 mL
1 mM	2.67 mL	13.36 mL	26.72 mL
5 mM	0.53 mL	2.67 mL	5.34 mL

*The above data is based on the productmolecular weight 374.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.