GSK 525762A (I-BET-762)

Catalog No. A11440

GSK 525762A (I-BET-762)是BET(溴域和末端外)家族的小分子抑制剂。

Technical details

Catalog Num	A11440
M. Wt	423.9
Formula	C22H22ClN5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1260907-17-2
Synonyms	GSK-525762A, GSK525762A
SMILES	CCNC(=O)C[C@H]1C2=NN=C(N2C3=C(C=C(C=C3)OC)C(=N1)C4=CC=C(C=C4)Cl)C

Biological Activity

GSK 525762A (I-BET-762)是BET(溴域和末端外)家族的小分子抑制剂。

Targets

BET proteins (Cell-free assay)
35 nM

Solubility *

In vitro	DMSO	72 mg/mL (169.84 mM)
	Water	Insoluble
	Ethanol	Warmed: 36 mg/mL (84.92 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.59 mL	117.95 mL	235.9 mL
0.5 mM	4.72 mL	23.59 mL	47.18 mL
1 mM	2.36 mL	11.8 mL	23.59 mL
5 mM	0.47 mL	2.36 mL	4.72 mL

*The above data is based on the productmolecular weight 423.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.