Istradefylline (KW-6002)

Catalog No. A11451

Istradefylline (KW-6002)是A2A受体的选择性拮抗剂。

Product Citations

PU Hamor, .et al. The Role of Glutamate mGlu5 and Adenosine A2a Receptor Interactions in Regulating Working Memory Performance and Persistent Cocaine Seeking in Rats, Prog Neuropsychopharmacol Biol Psychiatry, 2020, Dec 20;103:109979 PMID: 32470496

Technical details

Catalog Num	A11451
M. Wt	384.4
Formula	C20H24N4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	155270-99-8
Synonyms	KW-6002,KW6002
SMILES	CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OC)OC)C

Biological Activity

Istradefylline (KW-6002)是A2A受体的选择性拮抗剂。

Targets

Adenosine A2A receptor
2.2 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	5 mg/mL (13 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.01 mL	130.07 mL	260.15 mL
0.5 mM	5.2 mL	26.01 mL	52.03 mL
1 mM	2.6 mL	13.01 mL	26.01 mL
5 mM	0.52 mL	2.6 mL	5.2 mL

*The above data is based on the productmolecular weight 384.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.