TC-E 5001

Catalog No. A11454

TC-E 5001是双重tankyrase(TNKS)抑制剂(TNKS1和TNKS2的Kd值分别为79和28 nM,TNKS2的IC50 = 33 nM),在PARP1和PARP2上没有活性(IC50> 19 uM)。抑制Wnt信号并稳定Axin2水平。
Catalog Num A11454
M. Wt 409.46
Formula C20H19N5O3S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 865565-29-3
Synonyms TC-E5001, TC-E-5001
SMILES CC(N1C(C=C2)=CC=C2OC)=NN=C1SCC3=NC(C(C=C4)=CC=C4OC)=NO3
TC-E 5001是双重tankyrase(TNKS)抑制剂(TNKS1和TNKS2的Kd值分别为79和28 nM,TNKS2的IC50 = 33 nM),在PARP1和PARP2上没有活性(IC50> 19 uM)。抑制Wnt信号并稳定Axin2水平。
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.42 mL 122.11 mL 244.22 mL
0.5 mM 4.88 mL 24.42 mL 48.84 mL
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 409.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.