INK 128 (MLN0128)

Catalog No. A11461

INK 128是TORC1/2抑制剂，也是具有潜在抗肿瘤活性的猛禽mTOR（TOR复合物1或TORC1）和raptor-mTOR（TOR复合物2或TORC2）的口服生物利用抑制剂。

Product Citations

Ashlyn Parkhurst, .et al. Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors, Cell Death Dis, 2022, Apr 28;13(4):410 PMID: 35484114

Technical details

Catalog Num	A11461
M. Wt	309.3
Formula	C15H15N7O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1224844-38-5
Synonyms	INK128, INK-128
SMILES	CC(C)N1C2=C(C(=N1)C3=CC4=C(C=C3)OC(=N4)N)C(=NC=N2)N

Biological Activity

INK 128是TORC1/2抑制剂，也是具有潜在抗肿瘤活性的猛禽mTOR（TOR复合物1或TORC1）和raptor-mTOR（TOR复合物2或TORC2）的口服生物利用抑制剂。

Targets

Target	Value
mTOR	ki: 1.4nM
mTOR	ki: 1.4nM
PI3Kα	IC50: 219nM
PI3Kγ	IC50: 221nM
PI3Kδ	IC50: 230nM
PI3Kβ	IC50: 5293nM

Solubility *

In vitro (25°C)	DMSO	58 mg/mL (187.5 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (6.46 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.33 mL	161.66 mL	323.31 mL
0.5 mM	6.47 mL	32.33 mL	64.66 mL
1 mM	3.23 mL	16.17 mL	32.33 mL
5 mM	0.65 mL	3.23 mL	6.47 mL

*The above data is based on the productmolecular weight 309.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.