LRRK2-IN-1

Catalog No. A11477

LRRK2-IN-1抑制G2019S突变体和野生型LRRK2激酶活性，IC50值分别为6和13 nM。

Technical details

Catalog Num	A11477
M. Wt	570.09
Formula	C31H38N8O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1234480-84-2
Synonyms
SMILES	CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC

Biological Activity

LRRK2-IN-1抑制G2019S突变体和野生型LRRK2激酶活性，IC50值分别为6和13 nM。

Targets

Target	Value
DCLK1	IC50: 2.61nM
LRRK2(G2019S)	IC50: 6nM
LRRK2(WT)	IC50: 13nM
DCLK2	IC50: 45nM
LRRK2(A2016T)	IC50: 2.45μM
LRRK2(A2016T+G2019S)	IC50: 3.08μM

Solubility *

In vitro (25°C)	DMSO	97 mg/mL (169.96 mM)
	Water	Insoluble
	Ethanol	97 mg/mL (169.96 mM)
In vivo	Captisol	16 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.54 mL	87.71 mL	175.41 mL
0.5 mM	3.51 mL	17.54 mL	35.08 mL
1 mM	1.75 mL	8.77 mL	17.54 mL
5 mM	0.35 mL	1.75 mL	3.51 mL

*The above data is based on the productmolecular weight 570.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.