LDN193189 HCl

Catalog No. A11478

LDN193189 HCl是ldn193189的盐酸盐。LDN193189是一种高效的小分子BMP抑制剂，可抑制BMP I型受体ALK2（IC50：5 nM），ALK3（IC50：30 nM）和ALK6（TGFβ1/ BMP信号转导）以及随后的SMAD磷酸化。

Product Citations

Brandon J.Peiffer, .et al. Activation of BMP Signaling by FKBP12 Ligands Synergizes with Inhibition of CXCR4 to Accelerate Wound Healing, Cell Chem Biol, 2019, 26, 1-10

Technical details

Catalog Num	A11478
M. Wt	442.94
Formula	C25H22N6.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1062368-62-0
Synonyms	LDN 193189
SMILES	C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl.Cl.Cl.Cl

Biological Activity

Targets

ALK2 (C2C12 cells)	ALK3 (C2C12 cells)
5 nM	30 nM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.58 mL	112.88 mL	225.76 mL
0.5 mM	4.52 mL	22.58 mL	45.15 mL
1 mM	2.26 mL	11.29 mL	22.58 mL
5 mM	0.45 mL	2.26 mL	4.52 mL

*The above data is based on the productmolecular weight 442.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.