MEK162 (ARRY-438162, Binimetinib)

Catalog No. A11493

MEK162 (ARRY-438162,Binimetinib)是MEK1/2的一种强效、选择性ATP非竞争性抑制剂。

Product Citations

S Shahab, .et al. MEK Inhibition Suppresses Growth of Atypical Teratoid/Rhabdoid Tumors, J Neuropathol Exp Neurol, 2020, Jul 1;79(7):746-753
Seidel D, .et al. A multidimensional impedance platform for the real-time analysis of single and combination drug pharmacology in patient-derived viable melanoma models, Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332
Alquezar C, .et al. Increasing progranulin levels and blockade of the ERK1/2 pathway: Upstream and downstream strategies for the treatment of progranulin deficient frontotemporal dementia, Eur Neuropsychopharmacol, 2015, Mar;25(3):386-403 PMID: 25624003

Technical details

Catalog Num	A11493
M. Wt	440.0
Formula	C17H15BrF2N4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	606143-89-9
Synonyms	ARRY-162, MEK-162, MEK 162
SMILES	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO

Biological Activity

MEK162 (ARRY-438162,Binimetinib)是MEK1/2的一种强效、选择性ATP非竞争性抑制剂。

Targets

MEK
12 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 86 mg/mL (194.91 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% CMC+0.5% Tween-80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.73 mL	113.64 mL	227.27 mL
0.5 mM	4.55 mL	22.73 mL	45.45 mL
1 mM	2.27 mL	11.36 mL	22.73 mL
5 mM	0.45 mL	2.27 mL	4.55 mL

*The above data is based on the productmolecular weight 440.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.