Nutlin 3a

Catalog No. A11501

Nutlin 3a是与p53结合的MDM2(小鼠双分钟2)有效抑制剂,可诱导p53调控基因的表达,并在表达功能性p53的细胞中表现出有效的抗增殖活性。
  • Sho Watanabe, .et al. Schlafen 11 is a novel target for mucosal regeneration in Ulcerative Colitis, J Crohns Colitis, 2021, Feb 17 PMID: 33596306
  • Shun Zhang, .et al. Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation, BPB Reports, 2019, 2, 130-133
  • Momoko Ishimine, .et al. The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer, Dis Markers, 2018, 2018: 5280736 PMID: 29651325
Catalog Num A11501
M. Wt 581.49
Formula C30H30Cl2N4O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 675576-98-4
Synonyms Nutlin-3a, (-)-Nutlin-3
SMILES CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Nutlin 3a是与p53结合的MDM2(小鼠双分钟2)有效抑制剂,可诱导p53调控基因的表达,并在表达功能性p53的细胞中表现出有效的抗增殖活性。
Targets
p53/MDM2 interaction (Cell-free assay)
90 nM
In vitro (25°C) DMSO 98 mg/mL (168.53 mM)
Water Insoluble
Ethanol 98 mg/mL
In vivo 5% DMSO+55% PEG 300+ddH2O 7 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.2 mL 85.99 mL 171.97 mL
0.5 mM 3.44 mL 17.2 mL 34.39 mL
1 mM 1.72 mL 8.6 mL 17.2 mL
5 mM 0.34 mL 1.72 mL 3.44 mL

*The above data is based on the productmolecular weight 581.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.