NVP-TAE 226

Catalog No. A11507

NVP-TAE 226是一种强效FAK抑制剂，IC50为5.5 nM，对pyk2(IC50=3.5 nM)有适度的强效作用；对InsR, IGF-1R, ALK和c-Met的效力降低10-100倍。

Technical details

Catalog Num	A11507
M. Wt	468.94
Formula	C23H25ClN6O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	761437-28-9
Synonyms	TAE226, TAE 226
SMILES	CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCOCC4)OC

Biological Activity

NVP-TAE 226是一种强效FAK抑制剂，IC50为5.5 nM，对pyk2(IC50=3.5 nM)有适度的强效作用；对InsR, IGF-1R, ALK和c-Met的效力降低10-100倍。

Targets

Target	Value
PYK2	IC50: 3.5nM
FAK	IC50: 5.5nM
Insulin Receptor	IC50: 43.5nM
IGF-1R	IC50: 140nM
c-Met	IC50: 160nM
FLT4	IC50: 220nM
KDR	IC50: 360nM
FLT3	IC50: 480nM
CDK1/CyclinB	IC50: 540nM
Tek	IC50: 580nM
FGFR3(K650E)	IC50: 630nM
FGFR1	IC50: 750nM
JAK2	IC50: 840nM
c-Src	IC50: 905nM
HER2	IC50: 945nM
RET	IC50: 1.3μM
HER1	IC50: 1.7μM
RET(M918T)	IC50: 2.3μM
PDK-1	IC50: 2.4μM
PDGFRβ	IC50: 2.6μM
FLT1	IC50: 3.4μM
c-Abl	IC50: 5.85μM
ZAP70	IC50: 7.7μM
Syk	IC50: 7.9μM
PKA	IC50: >10μM
PKB	IC50: >10μM
C-Raf	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	93 mg/mL (198.32 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.32 mL	106.62 mL	213.25 mL
0.5 mM	4.26 mL	21.32 mL	42.65 mL
1 mM	2.13 mL	10.66 mL	21.32 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

*The above data is based on the productmolecular weight 468.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.