PF 477736

Catalog No. A11520

PF 477736是选择性检查点激酶1 (Chk1)抑制剂(Chk1和Chk2的ki值分别为0.49和47 nM)。

Technical details

Catalog Num	A11520
M. Wt	419.48
Formula	C22H25N7O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	952021-60-2
Synonyms	PF-0044736, PF0044736
SMILES	CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)[C@@H](C5CCCCC5)N

Biological Activity

PF 477736是选择性检查点激酶1 (Chk1)抑制剂(Chk1和Chk2的ki值分别为0.49和47 nM)。

Targets

Chk1 (Cell-free assay)	VEGFR2 (Cell-free assay)	Fms (Cell-free assay)	YES (Cell-free assay)	Chk2 (Cell-free assay)
0.49 nM(Ki)	8 nM(Ki)	10 nM(Ki)	14 nM(Ki)	47 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	5 mg/mL (11.92 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+40% PEG 300	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.84 mL	119.2 mL	238.39 mL
0.5 mM	4.77 mL	23.84 mL	47.68 mL
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL

*The above data is based on the productmolecular weight 419.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.