PSI-7977

Catalog No. A11529

PSI-7977是PSI-7851的氨基磷酸酯前药，PSI-7851是核苷类似物，当磷酸化时，抑制丙型肝炎病毒的RNA依赖性RNA聚合酶(EC50 = 92 nM)。

Product Citations

Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467

Technical details

Catalog Num	A11529
M. Wt	529.45
Formula	C22H29FN3O9P
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1190307-88-0
Synonyms	Sofosbuvir, PSI7977, GI-7977
SMILES	C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

Biological Activity

PSI-7977是PSI-7851的氨基磷酸酯前药，PSI-7851是核苷类似物，当磷酸化时，抑制丙型肝炎病毒的RNA依赖性RNA聚合酶(EC50 = 92 nM)。

Targets

NS5B polymerase

Solubility *

In vitro	DMSO	Warmed: 86 mg/mL (162.43 mM)
	Water	Warmed: 9 mg/mL (16.99 mM)
	Ethanol	86 mg/mL (162.43 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.89 mL	94.44 mL	188.88 mL
0.5 mM	3.78 mL	18.89 mL	37.78 mL
1 mM	1.89 mL	9.44 mL	18.89 mL
5 mM	0.38 mL	1.89 mL	3.78 mL

*The above data is based on the productmolecular weight 529.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.