Sotrastaurin (AEB071)
Catalog No. A11554
Sotrastaurin是一种有效的 pan-PKC 抑制剂,作用于PKCθ,PKCβ,PKCα,PKCη,PKCδ 和PKCε,Ki 分别为 0.22 nM,0.64 nM,0.95 nM,1.8 nM,2.1 nM 和 3.2 nM。用于预防移植排斥反应和治疗牛皮癣。
Catalog Num | A11554 |
---|---|
M. Wt | 438.5 |
Formula | C25H22N6O2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 425637-18-9 |
Synonyms | AEB 071, AEB-071 |
SMILES | CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65 |
Sotrastaurin是一种有效的 pan-PKC 抑制剂,作用于PKCθ,PKCβ,PKCα,PKCη,PKCδ 和PKCε,Ki 分别为 0.22 nM,0.64 nM,0.95 nM,1.8 nM,2.1 nM 和 3.2 nM。用于预防移植排斥反应和治疗牛皮癣。
Targets
Target | Value |
---|---|
PKCθ | ki: 0.22nM |
PKCβ1 | ki: 0.64nM |
PKCα | ki: 0.95nM |
PKCη | ki: 1.8nM |
PKCδ | ki: 2.1nM |
PKCε | ki: 3.2nM |
In vitro (25°C) | DMSO | 79 mg/mL (180.17 mM) | |
Water | Insoluble | ||
Ethanol | 2 mg/mL (4.56 mM) | ||
In vivo | 2% DMSO+30% PEG 300+ddH2O | 9 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.81 mL | 114.03 mL | 228.05 mL |
0.5 mM | 4.56 mL | 22.81 mL | 45.61 mL |
1 mM | 2.28 mL | 11.4 mL | 22.81 mL |
5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
*The above data is based on the productmolecular weight 438.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.