SU-5402

Catalog No. A11558

SU-5402是有效且选择性的血管内皮生长因子受体(VEGFR)和成纤维细胞生长因子受体(FGFR)抑制剂(在VEGFR2, FGFR1, PDGFRβ和EGFR处IC50值分别为0.02、0.03、0.51和> 100μM)。

Product Citations

Yan Zhang, etc. Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells. Cell Res. 2012 Apr; 22(4): 773–776.

Technical details

Catalog Num	A11558
M. Wt	296.32
Formula	C17H16N2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	215543-92-3
Synonyms	SU5402, SU 5402
SMILES	CC1=CNC(=C1CCC(=O)O)/C=C\2/C3=CC=CC=C3NC2=O

Biological Activity

Targets

VEGFR2	FGFR1	PDGFRβ
20 nM	30 nM	510 nM

Solubility *

In vitro	DMSO	54 mg/mL (182.23 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.75 mL	168.74 mL	337.47 mL
0.5 mM	6.75 mL	33.75 mL	67.49 mL
1 mM	3.37 mL	16.87 mL	33.75 mL
5 mM	0.67 mL	3.37 mL	6.75 mL

*The above data is based on the productmolecular weight 296.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.